UNMET NEED
The development of nanocarriers capable of encapsulating, targeting, and delivering Drug Substances (DS) has become the main challenging issue during the last three decades for biotechnology and pharmaceutical industries. Ideally, an optimal drug delivery system would be able to promote high encapsulation efficiency and adequate stability of DS in both storage and physiological conditions, while maintaining bioactive properties of loaded cargo. Moreover, the carrier platform would be easily modulated to target specific sites, allowing controlled spatial and temporal delivery of DS. Successful accomplishment of those hurdles has been expected to allow improvement of bioavailability of DS as well as to minimise side effects for patients. Lipid-based nanocarriers have been frequently proposed to achieve such mentioned requirements. In fact, the high volume of scientific papers, patents and companies interested in LNPs for gene delivery attest to the pertinency of such system in the pharmacotherapeutics field.
